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POROS® Bulk Chromatography Resin

High Performance Resin for Process-Scale Separations

When you need high performance and high throughput on a large scale, POROS® Bulk Chromatography Resins are the industry standard for process-scale bioseparations.

Utilized in multiple FDA regulated processes, these breakthrough resins combine optimal particle size and pore structure with a rigid backbone and proprietary chemistries. POROS® 50 µm resins demonstrate exceptionally high dynamic binding capacity, capture efficiency, and resolution over a range of flow rates.

POROS® products are manufactured in a state-of-the-art chromatography resin manufacturing facility and tested using the highest quality standards to support use in regulated biotherapeutic markets.

POROS XS Sample  

The new POROS® XS Cation Exchange Resin delivers:

  • Dynamic binding capacity for proteins, greater than 100 mg/mL at 5% breakthrough

  • High resolution using optimized 50 μm particle size for improved impurity clearance

  • Robust salt tolerance that maintains dynamic binding capacity to 150 mM NaCl (15 mS/cm)
Learn More about POROS® XS >

  • Ion Exchange Resin

    • POROS® XS 50 µm Bulk Resin
      A cation exchange resin that delivers the combination of high capacity, high resolution, and high salt tolerance can lead to increased process efficiency and help enable a faster time to market for the product.
    • POROS® HQ 50 µm Bulk Resin
      Strong Anion Echange Resin available for low pressure applications, including large scale downstream bioprocessing. POROS® HQ is based on a quaternized polyethyleneimine functional group yielding a high capacity, Perfusion Chromatography® media designed for the separation and purification of biomolecules.
    • POROS® PI 50 µm Bulk Resin
      Weak Anion Echange Resin for low pressure applications, including large scale downstream bioprocessing. POROS® PI is based on a polyethyleneimine functional group yielding a high capacity, Perfusion Chromatography® media designed for the separation and purification of biomolecules.

  • Affinity Resin

    • POROS® MabCapture™ A Resin
      New design in Protein A chromatography resin technology combines improvements made in bead and chemistry technology. These advances provide a monoclonal antibody purification media that not only demonstrates the highest dynamic binding performance at low flow rates but also one that can maintain superior binding capacity at high linear velocities where other chromatography resin products cannot operate.

    • POROS® Heparin 50 µm Bulk Resin
      Heparin affinity media for process scale separation of biomolecules with sepcific Heparin binding affinity, such as growth factors and other serum components, including coagulation factors and nucleotide binding proteins.

  • Reversed Phase Resin

    • POROS® R1 50 µm Bulk Resin
      Reversed-Phase Resin for low pressure applications, including large scale downstream bioprocessing. POROS® R1 is a 4000 angstrom pore size Poly (Styrene-Divinylbenzene) particle, suitable for the reversed-phase separation of biomolecules.
    • POROS® R2 50 µm Bulk Resin
      Reversed-Phase Resin for low pressure applications, including large scale downstream bioprocessing. POROS® R2 is a 2000 angstrom pore size Poly (Styrene-Divinylbenzene) particle, suitable for the reversed-phase separation of biomolecules.

  • Performance

  • Production

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