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Single-Stranded Conformation Polymorphism (SSCP)

Figure 1

Figure 1: Mutation Screening

Many researchers in the field of genomics need to be able to reliably identify allelic variants of genetic traits. Single-stranded conformation polymorphism (SSCP) is a widely used technique that can be an effective screening tool to find variants in a large number of samples, in everything from micro-organisms to humans. The SSCP analysis method detects point mutations by analyzing their unique electrophoretic mobility that results from small changes in the variant's nucleotide sequences. 

Mutation screening using SSCP analysis on an Applied Biosystems Genetic Analyzer and GeneMapper® Software (Figure 1). Gray bands indicate the expected peaks for three known mutations.

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