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SOLiD™ System Publications


Whole-Genome Sequencing for Optimized Patient Management

Publication: Science Translational Medicine, 15 June, 2011, Authors: Bainbridge M., et al.

Whole Genome sequencing of twins with dopamine responsive dystonia finds compound heterozygote mutations in the gene that is responsible for the production of a cofactor used in production of serotonin and dopamine (SPR). This genomic information was validated via Sanger sequencing, the validated variants highlighted additional molecules that could be targeted in treatment. 
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Platform/Technology



Accuracy of the SOLiD ™ System



Automation




Bioinformatics



Whole Genome Resequencing



Targeted Resequencing



Chromatin Immunoprecipitation Sequencing (ChIP-Seq)



Whole Transcriptome Analysis



Small RNA Analysis



Gene Expression




RNA Structure




Metagenomics


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